Best Digestive Enzyme Supplement of 2025
Ever eaten a delicious meal only to feel like there’s a cement mixer in your stomach afterward?
Digestive enzymes might be the answer. But with so many options, how do you choose?
I’ve done the research so you don’t have to. Let’s break down the top digestive enzyme supplements of 2025 – what works, what doesn’t, and what’s worth your money.
Designs for Health Digestzymes
Who’s it for? Anyone with chronic bloating, constipation, or trouble digesting fatty foods. If you’ve had your gallbladder removed, this should be on your radar. Also great for the lactose intolerant crowd thanks to its lactase content.
Sports Research Digestive Enzymes with Probiotics & Ginger
Who’s it for? Plant-based eaters who want more than just enzymes. If you’re looking for something that addresses gut health holistically, this is your pick.
MaryRuth Organics Ultra Digestive Enzymes
Who’s it for? People who want a no-nonsense, clean-label option without extra ingredients. Perfect if you’re sensitive to additives or just prefer simplicity.
Zenwise Health No Bloat Digestive Enzymes
Who’s it for? If your main issue is feeling like a balloon after meals, this is your go-to. The herbal ingredients add anti-inflammatory support that complements the enzyme action.
Designs for Health Digestzymes
Who’s it for? Anyone with chronic bloating, constipation, or trouble digesting fatty foods. If you’ve had your gallbladder removed, this should be on your radar. Also great for the lactose intolerant crowd thanks to its lactase content.
This is the heavyweight champion of digestive enzymes.
Digestzymes packs a serious punch with a broad-spectrum enzyme blend, betaine HCl, and ox bile extract. It’s basically the Swiss Army knife of digestion – breaking down proteins, fats, carbs, lactose, and even those pesky gluten peptides.
What’s cool? It’s manufactured to pharmaceutical-grade standards and third-party tested. Translation: you’re actually getting what the label promises.
The good:
- Covers literally everything – proteins, fats, carbs, dairy, and gluten/casein
- Quality you can trust (third-party tested)
- Users rave about reduced bloating and better digestion
The not-so-good:
- That betaine HCl is no joke – might irritate sensitive stomachs or those with ulcers
- Not cheap (quality rarely is)
Take 1 capsule with meals and watch your digestive woes disappear.
Sports Research Digestive Enzymes with Probiotics & Ginger
Who’s it for? Plant-based eaters who want more than just enzymes. If you’re looking for something that addresses gut health holistically, this is your pick.
The plant-based triple threat.
This vegan-friendly formula combines digestive enzymes with probiotics and ginger. It’s like getting three supplements in one – enzymes break down food, probiotics feed your gut bacteria, and ginger calms the whole system down.
The good:
- 100% vegan and non-GMO
- Added probiotics for gut health bonus points
- Ginger helps with nausea and digestive comfort
The not-so-good:
- Less transparent about enzyme potencies and probiotic strains
- More of a generalist than a specialist
MaryRuth Organics Ultra Digestive Enzymes
Who’s it for? People who want a no-nonsense, clean-label option without extra ingredients. Perfect if you’re sensitive to additives or just prefer simplicity.
The minimalist’s dream.
MaryRuth keeps it simple with a clean, vegan, non-GMO enzyme blend focusing on the basics – amylase, lipase, and lactase. No fancy additives, just straightforward digestive support.
The good:
- Clean, transparent formula
- Vegan and non-GMO friendly
- 60 capsules might last up to two months (value!)
The not-so-good:
- Basic enzyme profile (missing specialized enzymes)
- No added digestive support ingredients
Zenwise Health No Bloat Digestive Enzymes
Who’s it for? If your main issue is feeling like a balloon after meals, this is your go-to. The herbal ingredients add anti-inflammatory support that complements the enzyme action.
The bloat-buster.
Zenwise combines enzymes with probiotics and herbal ingredients like ginger, turmeric, and dandelion. It’s specifically designed to tackle gas and bloating – the most common digestive complaints.
The good:
- Triple action: enzymes + probiotics + herbs
- Specifically targets bloating and gas
- Herbal ingredients offer additional digestive comfort
The not-so-good:
- Not much detail on enzyme potencies or probiotic strains
- Herbal ingredients might not agree with everyone
Quick Comparison
| Product | Best For | Key Features | Potential Downsides |
|---|---|---|---|
| Designs for Health | Serious digestive issues | Comprehensive formula, HCl, ox bile | Pricey, potentially strong |
| Sports Research | Vegans | Plant-based, probiotics, ginger | Limited transparency |
| MaryRuth Organics | Clean label seekers | Simple, vegan, non-GMO | Basic formula |
| Zenwise Health | Bloating relief | Herbs, probiotics, anti-bloat | Possible herb sensitivity |
Bottom Line
Digestive enzymes work best for people with specific issues like lactose intolerance, pancreatic problems, or post-gallbladder removal struggles.
To get the most bang for your buck:
- Look for products listing enzyme activity units (HUT, USP, FIP)
- Take them right before or at the start of your meal
- If you have medical conditions or take medications, check with your doctor first
Whether you need the professional-grade comprehensive support of Designs for Health, the plant-based goodness of Sports Research, the clean simplicity of MaryRuth, or the bloat-busting power of Zenwise – there’s a digestive enzyme out there with your name on it.
Your gut will thank you.
